(Closed) (OM-TTR) Development of a sensor for biomarkers of transthyretin amyloidosis

Various diseases are known to be caused by accumulation of protein amyloid deposits in multiple sites in the body. This protein aggregation can lead to well-known conditions such as Parkinson’s, Alzheimer’s, and transthyretin amyloidosis (ATTR). There is an urgent need for effective ways to control or treat these conditions. One of the key factors in slowing the progression of amyloid diseases is early diagnosis. Current diagnostic methods for ATTR disease can only detect the final accumulation of the amyloid cascade, thus diagnosis only at the late stage of the disease.

This work aims to develop a novel, fast, and cost-effective diagnostic device for the measurement and detection of relevant protein monomers in plasma. The ability to identify these protein monomers will result in detection of amyloid accumulation in its early stages. The proposed device will utilize microfluidics and optical detection capabilities for selective capture and quantification of the protein monomers.